The Bag Adaptor Spike Port (SP) connects to IV bags and other containers with a proximal spike connector, creating a closed connection. It does not require priming. Its tail is transparent, which enables visual confirmation when spiking an IV set. In addition, the device does not have a twist-off spike port or a pinch clamp, thus requiring fewer handling steps. The Bag Adaptor SP enables simple dilution of the drug, and a safe drug transfer from a syringe to the IV container by connecting a Syringe Adaptor (SA) or Syringe Adaptor Lock (SAL) to the Bag Adaptor SP's side port with a simple click. The OnGuard 2 septum can be pierced up to 10 times, preventing drug leakage and contamination.